Computational model for monitoring cholesterol metabolism
نویسندگان
چکیده
منابع مشابه
A computational model of mitochondrial AZT metabolism.
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. T...
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ژورنال
عنوان ژورنال: Systems and Synthetic Biology
سال: 2014
ISSN: 1872-5325,1872-5333
DOI: 10.1007/s11693-014-9152-8